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Session:: New Frontiers in Cancer: From The Tumor Microenvironment to CARs

Novel Predictors of Treatment Response in Rectal Cancer

Tuesday, May 12, 2026
12:10 PM - 12:20 PM ET

    Faculty(s)

  • Campbell S. Roxburgh, PhD (he/him/his)

    Professor of Colorectal Surgical Oncology
    University of Glasgow
    University of Glasgow
    Glasgow, Scotland, United Kingdom

    All disclosed relationships have been reviewed and managed prior to the start of this activity. Any relevant relationships will be listed below. Agenus: Advisor or Review Panel Member (Terminated); AstraZeneca: Clinical Trial Investigator (Ongoing), Grant/Research Support (Ongoing); GSK: Advisor or Review Panel Member (Ongoing), Clinical Trial Investigator (Ongoing), Grant/Research Support (Ongoing); Intuitive Surgical: Teaching (Ongoing); Varian: Grant/Research Support (Ongoing)

This presentation will provide an update on how the rectal tumour environment shapes neoadjuvant treatment response in mismatch repair proficient rectal cancer. Attendees will learn how pre treatment immune activity and immune responses measured after initiation of treatment play important roles in determining outcome. In addition, novel strategies for targeting the immune compartment in the management of pMMR rectal cancer will be outlined.