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J. Joshua Smith, MD, PhD

Professor and Chair, Colon and Rectal Surgery Department
MD Anderson Cancer Center
MD Anderson Cancer Center
Houston, TX, United States

J. Joshua Smith, M.D., Ph.D. is Professor and Chair of the Department of Colon and Rectal Surgery at MD Anderson Cancer Center. The Department consists of 13 surgeons in Houston, 3 in Austin, 3 fellows, 14 APPs and 18 administrative/support staff. At MDACC, his objective as a surgeon and scientist is to lead the premier Colorectal Surgery Department in the world and uncover more precise treatments for each individual rectal and colon cancer patient. He actively cares for patients with rectal, colon, and anal cancer using modern surgical methods in a cutting-edge multidisciplinary setting. He was previously Associate Member and Associate Attending on the Colorectal Service in the Department of Surgery at MSK. He is the co-Chair of the GI Oncology portfolio for the Alliance for Clinical Trials in Oncology, the co-chair of the GI Surgery Committee for the Alliance for Clinical Trials in Oncology, and is a member of the NCI's Rectal Anal Task Force.
He serves as the Chair and Primary Investigator for the Janus Rectal Cancer Trial, an NCI-approved Phase II/III trial (now completed) that is investigating clinical complete response and nonoperative management (NOM) in patients with rectal cancer through the Alliance for Clinical Trials in Oncology, SWOG and NRG Oncology. He was an active co-investigator for the paradigm-changing, randomized trial integrating NOM for selected patients with rectal cancer (NCT02008656 – The OPRA Trial). He leads an NCI-funded laboratory to understand the molecular underpinnings of disease progression in patients with rectal cancer and to develop individualized disease models facilitating both effective research and precision treatment.

ORCID: 0000-0003-2538-5456
https://pubmed.ncbi.nlm.nih.gov/?term=smith+jj+and+memorial+sloan&sort=date

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