EP623 - Impact of obesity on short- and long-term oncologic outcomes after sphincter-preserving surgery for ultra-low rectal cancer: A propensity score-matching analysis

ePoster Presenter(s)

• 

  Haoying Wu (she/her/hers)

  Bachelor Student
  West China School of Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China.
  West China School of Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China.
  Chengdu, Sichuan, China (People's Republic)

  Disclosure information not submitted.

Author(s)

• ZD

  Zekun Du

  Chengdu
  West China Hospital,Sichuan University
  West china hospital,Sichuan university
  Chengdu, Sichuan, China (People's Republic)

  All of the relevant financial relationships listed below have been mitigated.
  This individual has no financial relationships with ineligible companies.
• ll

  li li, n/a

  surgeon
  West China Hospital, Sichuan University
  Chengdu, Sichuan, China (People's Republic)

  Disclosure information not submitted.
• MW

  Mingtian Wei, n/a

  associate senior doctor
  West China Hospital, Sichuan University
  chengdu city, Sichuan, China (People's Republic)

  Disclosure information not submitted.
• YY

  Yun Yang, -

  Attending Surgeon
  WCH, SCU
  Chengdu, Sichuan, China (People's Republic)

  Disclosure information not submitted.
• TH

  Tao Hu, n/a

  Attending physician
  Department of Gastrointestinal Surgery, Chengdu Shang Jin Nan Fu Hospital, Shang Jin Hospital of West China Hospital, Sichuan University
  chengdu, Sichuan, China (People's Republic)

  Disclosure information not submitted.
• XY

  Xuyang Yang, Licensed physician

  attending doctor
  west china hospital
  CHENGDU, Sichuan, China (People's Republic)

  Disclosure information not submitted.

Senior Author(s)

• XW

  Xiaodong Wang, Chinese Medical Doctor Association

  Deputy Chief Physician
  West China Hospital
  Chengdu, Sichuan, China (People's Republic)

  Disclosure information not submitted.

Purpose/Background: Obesity narrows the pelvic operative field and increases technical difficulties during colorectal surgery, potentially leading to an increased risk of complications and poor long-term survival. However, its independent impact on short-term complications and long-term survival specifically in ultra-low rectal cancer patients undergoing sphincter-preserving surgery remains incompletely defined.

Methods/Interventions: A retrospective analysis was conducted on patients with ultra-low rectal cancer who underwent sphincter-preserving surgery. Patients were classified into high-BMI (BMI ≥28 kg/m²) and lower-BMI groups (BMI < 28 kg/m²) based on Chinese BMI standards. Propensity score matching was employed to balance variables such as age, gender, comorbidities, tumor characteristics and surgical details, establishing comparable cohorts of 35 high-BMI patients and 79 lower-BMI patients. Outcomes assessed included short-term results and long-term survival metrics.

Results/Outcomes: The study revealed no significant associations between high BMI and short-term postoperative complications or long-term survival outcomes. However, disease-free survival (DFS) was potentially influenced by the distance from the tumor to the anal verge, intestinal perforation or intussusception, and diabetes.

Conclusion/Discussion: A high BMI does not appear to independently impact short-term complications or long-term survival in ultra-low rectal cancer patients undergoing sphincter-preserving surgery. Future studies incorporating measures of visceral adiposity and larger prospective cohorts are needed to further evaluate the relationships between obesity and short- and long-term oncologic outcomes.

The multivariable Cox regression analysis for DFS