EP517 - Sepsis Risk and Management of Acute Anorectal Pathology in Patients with Hematologic Disease: A Single-Center Retrospective Study

Sunday, May 10, 2026

2:08 PM - 2:13 PM ET

ePoster Presenter(s)

Marco A. Urbina Velázquez, Universidad Nacional Autónoma de México (he/him/his)

Colorectal Surgery Fellow
Centro Médico ABC Ciudad de México
American British Cowdray
Ciudad de México, Mexico City, Mexico

Disclosure information not submitted.

Author(s)

Andric Perez-Ortiz, MD, MPH (he/him/his)

Colorectal Surgery Fellow
The American British Cowdry Medical Center
The American British Cowdray Medical Center
CDMX, Distrito Federal, Mexico

Disclosure information not submitted.
RM

Raul Moran Treviño, MD

Colorectal surgery fellow
The American British Cowdray Medical Center
México City, Distrito Federal, Mexico

Disclosure information not submitted.
AZ

Asya Zubillaga, MD

Hospital General Dr Manuel Gea Gonzalez

Disclosure information not submitted.
EG

Edgar A. Gonzalez Macedo, MD, Certified General Surgeon, Certified Colorectal Surgeon

Associate professor
ABC Medical Center
Mexico City, Distrito Federal, Mexico

Disclosure information not submitted.
JM

Juan F. Molina López, MD, MSc, PhD

Colorectal surgeon staff
ABC Medical Center
Mexico City, Distrito Federal, Mexico

Disclosure information not submitted.
AD

Ana Domínguez Merino, MD

Intern
The American British Cowdry Medical Center
Mexico City, Distrito Federal, Mexico

Disclosure information not submitted.
JG

José Emiliano González Flores, MD

Intern
The American British Cowdray Medical Center
Mexico City, Distrito Federal, Mexico

Disclosure information not submitted.

Senior Author(s)

CD

César Decanini, n/a

Chair of Surgery Department
ASCRS
Mexico city, Distrito Federal, Mexico

Disclosure information not submitted.

Purpose/Background: Anorectal infections are a common complication in patients with hematologic malignancies undergoing chemotherapy, particularly in the setting of neutropenia. However, regional evidence on clinical outcomes and medical vs. surgical management is limited. Here, we aimed to describe the clinical characteristics, disease progression, and risk factors associated with morbidity and mortality in patients with hematologic diseases who developed acute anorectal pathologies.

Methods/Interventions: We conducted a retrospective cohort study between 2014 and 2024 in a tertiary care center. Adult patients with a diagnosis of malignant or benign hematologic diseases who developed acute anorectal pathology and underwent surgical intervention were included. Clinical, laboratory, surgical, and 30-day outcome variables were abstracted from electronic medical records. We conducted bivariate analyses stratified by sepsis status and management (upfront medical vs. upfront surgical) in R v.4.2.2.

Results/Outcomes: Of 56 included patients, the mean age was 50 (± 17) years, and they were predominantly male (2:1). The most frequently diagnosed anorectal disease was perianal abscess (40 %), followed by hemorrhoidal disease (35 %). Sepsis occurred in 30 % and was significantly associated with hematologic malignancies (OR: 5.6; p = 0.0027) and perianal abscess diagnosis (93 %; p = 0.0003). Neutropenia was present in 10 % and associated with older age, low BMI, and a greater need for MRI. All patients who initially received conservative management failed and ultimately underwent surgery. No 30-day mortality was recorded.

Conclusion/Discussion: Sepsis is a frequent complication in hematologic patients with acute anorectal disease, particularly in those with active malignancy. Early surgical management, even in neutropenic patients, may reduce complications. More evidence is warranted.